Caenorhabditis elegans
CDK-1
CELE_T05G5.3, ncc-1, T05G5.3
cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis; in regulating progression through meiosis and the oocyte-to-egg transition, CDK-1 functions to regulate the activity of the MBK-2 DYRK2 family kinase that phosphorylates a number of substrates to promote the oocyte-to-egg transition; CDK-1 physically interacts with CYB-1 and CYB-3 and demonstrates cyclin-dependent kinase activity in vitro; CDK-1 expression is detected at high levels in embryos, but is also seen in larvae and adults; CDK-1 localizes to nuclei and to the cytoplasm.
GO Process (15)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cell division [IMP]
- collagen and cuticulin-based cuticle development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic nuclear division [IMP]
- mitotic nuclear division [IMP]
- oocyte maturation [IMP]
- oogenesis [IMP]
- positive regulation of meiosis [IMP]
- positive regulation of meiotic cell cycle [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP]
- pronuclear migration [IMP]
- protein phosphorylation [IDA]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
41569
6239
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- Interactors 14
- Interactions 20
- Network