CELE_T07C4.1, T07C4.1

umps-1 encodes an ortholog of the bifunctional mammalian enzyme uridine-5'-monophosphate synthase (UMPS); UMPS-1 catalyzes the conversion of orotic acid to UMP during pyrimidine biosynthesis; C. elegans UMPS-1 demonstrates both the orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase activities invitro, that are required for the conversion of orotic acid to UMP; umps-1 is required for embryonic and larval viability and the proper formation and morphology of gut granules which are lysosome-related organelles; umps-1 mutants show enlargement of gut granules likely through a build-up of orotic acid; umps-1 localizes to the cytoplasm.

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