Caenorhabditis elegans


CELE_Y47D3B.7, lpd-1, hlh-20, Y47D3B.7
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; in addition, sbp-1 is required for mediating the lipid accumulation and increased body width/length ratio that occurs in response to oxygen deprivation; sbp-1 expression is detected in the intestine, the major site of fat storage, from early embryogenesis through adulthood and also in the amphid neurons.

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WormBase | Entrez Gene | RefSeq | UniprotKB
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