Caenorhabditis elegans
SBP-1
CELE_Y47D3B.7, lpd-1, hlh-20, Y47D3B.7
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; in addition, sbp-1 is required for mediating the lipid accumulation and increased body width/length ratio that occurs in response to oxygen deprivation; sbp-1 expression is detected in the intestine, the major site of fat storage, from early embryogenesis through adulthood and also in the amphid neurons.
GO Process (16)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- lipid metabolic process [IMP]
- lipid storage [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- positive regulation of lipid storage [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of gene expression [IMP]
- regulation of multicellular organism growth [IMP]
- reproduction [IMP]
- response to anoxia [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Download Curated Data for this Protein
41755
6239
Switch View:
- Interactors 6
- Interactions 7
- Network