CELE_Y49E10.15, Y49E10.15

snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.

41847

6239