Caenorhabditis elegans
LIS-1
CELE_T03F6.5, pnm-1, T03F6.5
lis-1 encodes a microtubule-association protein (MAP) that is orthologous to human LIS1, and Aspergillus nidulans nudF, which mediates nuclear migration along Aspergillus hyphae; in C. elegans lis-1 functions as a dynein regulator whose activity is required for a number of processes, including centrosome separation, spindle assembly, regulation of neurotransmission, and actin cytoskeleton integrity; LIS-1 localizes to the cytoplasm, nucleus, and microtubules.
GO Process (14)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- chiasma assembly [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- establishment of mitotic spindle orientation [IMP]
- locomotion [IMP]
- microtubule-based movement [IMP]
- mitotic centrosome separation [IMP]
- mitotic spindle organization [IMP]
- pronuclear migration [IMP]
- reproduction [IMP]
- spindle assembly [IMP]
- synaptic transmission, GABAergic [IGI, IMP]
- synaptic vesicle transport [IMP]
- vulval development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
41927
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- Interactors 39
- Interactions 40
- Network