Caenorhabditis elegans
CYK-4
CELE_K08E3.6, K08E3.6
cyk-4 encodes a Rho GAP (Rho guanosine triphosphatase (GTPase) activating protein); during development, cyk-4 is required for two different processes: 1) paternally provided CYK-4 regulates anterior-posterior polarity in the one-cell embryo by controlling the actomyosin cytoskeletal network, and 2) together with ZEN-4, CYK-4 is sufficient to promote formation of the large bundles of microtubules that form the central spindle during anaphase and polarize the foregut epithelium; in addition, CYK-4 is required for fertility and coordinated locomotion postembryonically; CYK-4 is enriched in sperm and also localizes to the central spindle during anaphase interdependently with ZEN-4; CYK-4 interacts with ZEN-4 in vitro and in vivo.
GO Process (14)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [IMP]
- body morphogenesis [IMP]
- cytokinesis [IMP]
- cytokinesis, completion of separation [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- mitotic cytokinesis [IMP]
- polar body extrusion after meiotic divisions [IMP]
- positive regulation of Cdc42 GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
41980
6239
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- Interactors 19
- Interactions 26
- Network