Caenorhabditis elegans
DAF-18
CELE_T07A9.6, T07A9.6
daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- dauer entry [IMP]
- dauer larval development [IGI]
- determination of adult lifespan [IGI, IMP]
- learning or memory [IMP]
- negative regulation of transcription factor import into nucleus [IGI]
- peptidyl-tyrosine dephosphorylation [IMP]
- protein dephosphorylation [IMP]
- regulation of chemotaxis [IMP]
- response to heat [IGI]
- vulval development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
42030
6239
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- Interactors 9
- Interactions 12
- Network