Caenorhabditis elegans
CMK-1
CELE_K07A9.2, Ce-CaM-KI, K07A9.2
cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; when expressed in COS-7 cells, CMK-1 and CKK-1 positively regulate the transcriptional activity of endogenous CREB; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; in the AFD neurons, CMK-1 localizes exclusively to the cytoplasm, however when expressed in COS-7 cells, CMK-1 is seen in the nucleus.
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- neuron projection morphogenesis [IMP]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of neuron differentiation [IMP]
- thermosensory behavior [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
42145
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- Interactors 5
- Interactions 6
- Network