CELE_Y54G2A.31, Y54G2A.31

ubc-13 encodes an E2 ubiquitin-conjugating enzyme; by homology, UBC-13 is predicted to function in the covalent attachment of ubiquitin molecules to protein substrates, via its association with an E3 ubiquitin-protein ligase; UBC-13 physically interacts with the UEV-1 ubiquitin-conjugating enzyme variant, and like UEV-1, ubc-13 mutations result in defects in GLR-1 glutamate receptor trafficking and hence, abnormal locomotory behavior; in large-scale RNAi screens, loss of ubc-13 activity also results in embryonic lethality and reduced brood size.

42218

6239