CELE_F32E10.4, F32E10.4

ima-3 encodes one of three C. elegans importin alpha nuclear transport factors and the importin alpha that is most similar to the alpha3-subtype; ima-3 activity is required throughout development: during oogenesis, ima-3 is essential for progression past pachytene of meiotic prophase I and for proper organization of the nuclear pore complex (NPC) as well as association of P granules with the NPC; ima-3 is also required for normal embryonic, larval, and germline development; in vitro, IMA-3 can interact with human importin beta1, suggesting that it functions in a complex with C. elegans importin betas in vivo; IMA-3 is expressed in males and hermaphrodites, in both the germline and in somatic tissue; in the germline, IMA-3 is seen in the common cytoplasm of the rachis and in association with the nuclear envelope of germline nuclei and the residual body of developing spermatids.

42651

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