CELE_T14A8.1, des-5, T14A8.1

ric-3 encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; RIC-3 is necessary for the maturation and function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor; RIC-3 levels and hence, activity, are regulated by BATH-42, a BTB and MATH domain-containing protein, with which RIC-3 interacts in vitro; as BATH-42 also interacts with the CUL-3 cullin, RIC-3 levels are thus likely regulated by a CUL-3-containing ubiquitin ligase complex.

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