CELE_T01B11.3, syn-4, T01B11.3

syx-4 encodes a syntaxin-related t-SNARE; t-SNARES function as receptor for intracellular transport vesicles during membrane fusion reactions and in C. elegans, SYX-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYX-4 plays a role in formation of the vitelline membrane and/or eggshell, as SYX-4 is required for regulated secretion of CAV-1-containing cortical granules following fertilization; SYX-4 is expressed in cortical granules, the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYX-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYX-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.

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