CELE_W01B6.1, Wnt-2, W01B6.1

cwn-2 encodes one of five C. elegans Wnt signaling molecules that is homologous to mammalian Wnt5; cwn-2 is required for proper placement of the nerve ring and anterior cells along the anterior/posterior axis; cwn-2 also acts redundantly to specify cell fates during vulval development; CWN-2 appears to be required at the time of nerve ring development (comma stage of embryogenesis) for nerve ring placement and likely functions as a signaling ligand for receptors, such as CAM-1, that regulate axon guidance of the SIA and SIB neurons that plays a role in nerve ring placement; CWN-2, along with LIN-17, CAM-1, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; in embryos at the comma stage, a cwn-2::gfp reporter is expressed in the intestine and in pharyngeal muscle; in larvae and adults, cwn-2::gfp is seen in the intestine, pharynx, anterior body wall muscle, vulva and SMD head neurons.

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