Caenorhabditis elegans

GST-4

CELE_K08F4.7, CeGST1, K08F4.7
gst-4 encodes a putative glutathione-requiring prostaglandin D synthase; gst-4 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; gst-4(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, prostaglandin D synthase is required for the conversion of prostaglandin H2 into D2; gst-4 mRNA is expressed in adults, and accumulation increases in response to paraquat.
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