The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis.

Scinderin (Sc), a Ca(2+)-regulated actin-binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F-actin dynamics during secretion.
Mesh Terms:
Actins, Animals, Binding Sites, Cell Membrane, Chromaffin Cells, Cytoskeleton, Cytosol, Exocytosis, Gelsolin, Microfilament Proteins, Microscopy, Confocal, Protein Structure, Tertiary, Transfection
Ann. N. Y. Acad. Sci.
Date: Oct. 01, 2002
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