Caenorhabditis elegans
LET-60
CELE_ZK792.6, lin-34, ZK792.6
let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages.
GO Process (17)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- muscle organ development [IGI, IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IGI, IMP]
- oogenesis [IGI]
- positive regulation of Rap GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of vulval development [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell projection organization [IGI, IMP]
- reproduction [IGI, IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
43199
6239
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- Interactors 142
- Interactions 166
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