CELE_F35G2.4, F35G2.4

phy-2 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (II) isoform (OMIM: 600608); phy-2 is responsible for hydroxylation of cuticle collagen; loss-of-function mutations result in phenotypically wild-type animals, however phy-1; phy-2 double mutants arrest as embryos and larvae, suggesting that the PHY-1 and PHY-2 P2H alpha subunits function redundantly during development; phy-2 in complex with phy-1 is essential for the survival of the C. elegans; PHY-2, are expressed in the cuticle collagen-synthesizing hypodermal cells in a cyclical fashion that corresponds the moulting cycle and the times of maximal cuticle collagen synthesis; phy-2 is also expressed excretory cell, and spermatheca.

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