Caenorhabditis elegans
HIM-6
CELE_T04A11.6, blm-1, T04A11.6
him-6 encodes a RecQ-like ATP-dependent DNA helicase orthologous to human BLM (OMIM:604610, mutated in Bloom syndrome); HIM-6 is required for normal levels of recombination during meiosis and as such, loss of HIM-6 function results in an increased frequency of genotypically XO males and inviable aneuoploid embryos as a result of higher levels of chromosome nondisjunction; HIM-6 interacts both genetically and in vitro with TOP-3, DNA topoisomerase IIIalpha, with which it functions to regulate genomic stability during germ-line mitosis; HIM-6 is expressed primarily in the germ line.
GO Process (10)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- chromosome organization [IGI]
- chromosome segregation [IGI]
- determination of adult lifespan [IMP]
- meiotic chromosome separation [IMP]
- meiotic nuclear division [IGI]
- mitotic nuclear division [IGI]
- negative regulation of apoptotic process [IMP]
- reciprocal meiotic recombination [IMP]
- response to X-ray [IMP]
Gene Ontology Molecular Function
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43294
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- Interactors 9
- Interactions 14
- Network