CELE_R09E12.3, R09E12.3

sti-1 encodes the C. elegans ortholog of the Sti1/Hop family of heat shock cochaperones; sti-1 plays a role in stress response, as sti-1 mutant animals have a shortened lifespan, decreased fertility at 20C, 25C, and 30C, and decreased thermotolerance; genetic interaction studies suggest that sti-1 may function together with daf-16 in regulating thermotolerance; STI-1 physically interacts with a number of proteins including HSP-1/Hsp70 and DAF-21/Hsp90, as well as proteins involved in translation and localized to the endoplasmic reticulum; a STI-1::GFP reporter is widely expressed in embryos as well as larvae and adults, with expression found in the pharynx, intestine, neurons, vulva, body wall muscles and male sensory rays; STI-1 appears to be a cytoplasmic protein.

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