Interaction of human recombination proteins Rad51 and Rad54.
The cDNA for human protein HsRad54, which is a structural homolog of Saccharomyces cerevisiae recombination/repair protein Rad54, was cloned and expressed in Escherichia coli. As demonstrated by analysis in vitro and in vivo, HsRad54 protein interacts with human Rad51 recombinase. The interaction is mediated by the N-terminal domain of HsRad54 ... protein, which interacts with both free and DNA-bound HsRad51 protein.
Mesh Terms:
Blotting, Western, Cloning, Molecular, DNA, DNA Repair Enzymes, DNA-Binding Proteins, Drug Interactions, Escherichia coli, Fungal Proteins, Gene Expression, Humans, Peptide Fragments, Rad51 Recombinase, Recombinant Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Blotting, Western, Cloning, Molecular, DNA, DNA Repair Enzymes, DNA-Binding Proteins, Drug Interactions, Escherichia coli, Fungal Proteins, Gene Expression, Humans, Peptide Fragments, Rad51 Recombinase, Recombinant Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Nucleic Acids Res.
Date: Oct. 15, 1997
PubMed ID: 9321665
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