Caenorhabditis elegans


CELE_Y73C8B.4, let-461, sel-3, Y73C8B.4
lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex.
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