Caenorhabditis elegans
NLP-29
CELE_B0213.4, B0213.4
nlp-29 encodes an antimicrobial, neuropeptide-like protein; nlp-29 appears to play a role in innate immunity, as its expression in the epidermis is strongly induced following fungal infection; nlp-29 expression is also induced following physical injury and osmotic stress; nlp-29 expression following fungal infection or physical wounding is regulated by a TIR-1, (Toll-interleukin 1 receptor (TIR) domain protein)/NSY-1/SEK-1/PMK-1 p38 MAPK signaling pathway and the ELT-3 GATA transcription factor; nlp-29 expression in the epidermis is also regulated by the SNF-12 sodium-dependent neurotransmitter symporter acting in concert with the STA-2 STAT transcription factor; the RAB-1 GTPase and the product of R53.4, a mitochondrial ATP synthase subunit f homolog, also appear to play a role in nlp-29 regulation; several reports indicate that nlp-29 is expressed exclusively in the hypodermis, while one report additionally reported expression in the intestine.
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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