CELE_B0213.4, B0213.4

nlp-29 encodes an antimicrobial, neuropeptide-like protein; nlp-29 appears to play a role in innate immunity, as its expression in the epidermis is strongly induced following fungal infection; nlp-29 expression is also induced following physical injury and osmotic stress; nlp-29 expression following fungal infection or physical wounding is regulated by a TIR-1, (Toll-interleukin 1 receptor (TIR) domain protein)/NSY-1/SEK-1/PMK-1 p38 MAPK signaling pathway and the ELT-3 GATA transcription factor; nlp-29 expression in the epidermis is also regulated by the SNF-12 sodium-dependent neurotransmitter symporter acting in concert with the STA-2 STAT transcription factor; the RAB-1 GTPase and the product of R53.4, a mitochondrial ATP synthase subunit f homolog, also appear to play a role in nlp-29 regulation; several reports indicate that nlp-29 is expressed exclusively in the hypodermis, while one report additionally reported expression in the intestine.

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