Caenorhabditis elegans


CELE_C04F5.3, C04F5.3
unc-46 encodes a type I transmembrane protein that contains a single motif similar to the LAMP (lysosomal associated membrane glycoprotein) domain; UNC-46 and UNC-47, the C. elegans vesicular GABA transporter, are required in GABAergic neurons for loading GABA into synaptic vesicles and thus, for all GABA-mediated behaviors; a rescuing UNC-46::GFP fusion protein localizes to synaptic varicosities in the dorsal and ventral nerve cords; UNC-46 and UNC-47 are mutually required for sorting/localization to synaptic vesicles; when overexpressed, unc-47 can rescue unc-46 mutant animals.
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