Caenorhabditis elegans


CELE_C24G6.1, C24G6.1
syp-2 encodes a coiled-coil protein; during meiosis, syp-2 activity is required for the normal progression of chromosome organization in the nucleus, for maintaining stable pairing between homologous chromosomes subsequent to initial pairing, and for productive crossover events and chiasmata formation; SYP-2 localizes to the region between paired homologous chromosomes during pachytene and disappears from this interface by late diakinesis, suggesting that SYP-2 is a structural component of the central element of the synaptonemal complex (SC); SYP-2 localization to the SC is dependent upon activity of HIM-3 and REC-8, meiosis-specific axis components, while SYP-1, an additional SC component, and SYP-2 are interdependent for localization to the SC.
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  • Interactors 5
  • Interactions 7
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