Caenorhabditis elegans
RGA-3
CELE_K09H11.3, K09H11.3
rga-3 encodes a GTPase-activating protein (GAP); RNAi experiments predicted to target rga-3 and the related rga-4 gene result in early embryonic defects, specifically defects in cortical contractility, non-muscle myosin NMY-2 distribution, and the relative size of PAR protein domains; in vitro, RGA-3 positively regulates RHO-1 GTPase activity, consistent with genetic studies showing that the rga-3/4(RNAi) phenotype requires RHO-1 activity; in early embryos, a YFP-RGA-3 fusion protein localizes to the cellular cortex and to centrosomes, with cortical localization segregating to the anterior during polarization.
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download 3 Published Interactions For This Protein
44010
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- Interactions (3)
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