Caenorhabditis elegans
LET-418
CELE_F26F12.7, chd-4, evl-11, F26F12.7
The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline.
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- embryonic digestive tract morphogenesis [IGI]
- hermaphrodite genitalia development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
44019
6239
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- Interactors 13
- Interactions 18
- Network