Caenorhabditis elegans


CELE_K08B12.5, tag-59, K08B12.5
mrck-1 encodes a serine/threonine-protein kinase that is orthologous to human MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) and DMPK (dystrophia myotonica-protein kinase, OMIM:605377); during development, MRCK-1 functions together with LET-502/ROCK to effect embryonic elongation through regulation of the MLC-4/myosin regulatory light chain; an MRCK-1::GFP fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells, as well as in the dorsal and ventral hypodermis, the pharynx, and the dorsal and ventral nerve cords; in the hypodermal cells, MRCK-1::GFP forms parallel bundles, consistent with co-localization with filamentous actin and the non-muscle myosin II complex.
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