Caenorhabditis elegans
DBL-1
CELE_T25F10.2, cet-1, T25F10.2
dbl-1 encodes a member of the transforming growth factor beta (TGFbeta) superfamily that includes Drosophila decapentaplegic (Dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions as a dose-dependent ligand for the SMA-6 and DAF-4 TGFbeta receptors that ultimately activate the SMA-2, -3, and -4 complex of transcription factors to regulate body length and size, as well as the patterning of male sensory rays and copulatory spicules; DBL-1 signaling upregulates sma-6 expression, suggesting that there is positive autoregulation in the DBL-1 signaling pathway; in contrast, DBL-1 negatively regulates expression of LON-1, a predicted secreted protein that is a downstream component of the body size pathway; in addition to its other roles, the TGFbeta Sma/Mab pathway also regulates reproductive aging, mutants of the pathway show an extension of the reproductive span, independent of somatic longevity; DBL-1 is expressed primarily in neurons.
GO Process (13)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- defense response to Gram-negative bacterium [IMP]
- defense response to Gram-positive bacterium [IMP]
- defense response to fungus [IMP]
- innate immune response [IMP]
- nematode larval development [IMP]
- nematode male tail tip morphogenesis [IMP]
- positive regulation of DNA endoreduplication [IMP]
- positive regulation of cell size [IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of organ growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
44113
6239
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- Interactors 3
- Interactions 3
- Network