Caenorhabditis elegans

DBL-1

CELE_T25F10.2, cet-1, T25F10.2
dbl-1 encodes a member of the transforming growth factor beta (TGFbeta) superfamily that includes Drosophila decapentaplegic (Dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions as a dose-dependent ligand for the SMA-6 and DAF-4 TGFbeta receptors that ultimately activate the SMA-2, -3, and -4 complex of transcription factors to regulate body length and size, as well as the patterning of male sensory rays and copulatory spicules; DBL-1 signaling upregulates sma-6 expression, suggesting that there is positive autoregulation in the DBL-1 signaling pathway; in contrast, DBL-1 negatively regulates expression of LON-1, a predicted secreted protein that is a downstream component of the body size pathway; in addition to its other roles, the TGFbeta Sma/Mab pathway also regulates reproductive aging, mutants of the pathway show an extension of the reproductive span, independent of somatic longevity; DBL-1 is expressed primarily in neurons.

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WormBase | Entrez Gene | RefSeq | UniprotKB
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