Caenorhabditis elegans
RUVB-1
CELE_C27H6.2, C27H6.2
ruvb-1 encodes a AAA+ ATPase orthologous to the RUVBL1 family of ATPases; ruvb-1 functions as a component of the TOR signaling pathway that promotes localization of the box C/D snoRNP complex to nucleoli, thus enabling robust protein synthesis; ruvb-1 mutations strongly suppress pha-4 mutations, suggesting that pha-4 and the CeTOR pathway antagonize one another to regulate larval development and adult lifespan; ruvb-1::gfp promoter fusions are expressed in most cells of the early embryo, but restricted to pharyngeal cells beginning at ~2-fold stage of embryogenesis.
GO Process (12)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- RNA interference [IMP]
- TOR signaling [IMP]
- body morphogenesis [IMP]
- box C/D snoRNP assembly [IMP]
- embryo development ending in birth or egg hatching [IMP]
- growth [IMP]
- hermaphrodite genitalia development [IMP]
- inductive cell migration [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- positive regulation of translation [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
44422
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- Interactors 19
- Interactions 25
- Network