CELE_C12D8.11, rop1, C12D8.11

rop-1 encodes an RNAi-binding protein that is orthologous to the vertebrate 60-kDa Ro autoantigen that is the protein component of the Ro ribonucleoprotein (RNP) complex; ROP-1 binds the single C. elegans Ro RNP RNA component, YRN-1 (Y RNA) in vivo and although loss of rop-1 activity via mutation results in no obvious visible phenotypes, it does result in a dramatic decrease in YRN-1 levels, indicating that ROP-1 is necessary for maintaining normal levels of the Ro RNP Y RNA; in addition, rop-1 mutations also result in a statistically significant increase in mutant 5S rRNA molecules found in ribosomal RNA preparations, suggesting that ROP-1 may play a role in quality control of 5S rRNA processing; rop-1 mRNA is detectable during all stages of development, and rop-1 promoter fusions appear to be expressed in all cell types, except the germline.

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