Caenorhabditis elegans

LYS-1

CELE_Y22F5A.4, Y22F5A.4
lys-1 encodes a putative lysozyme, whose overexpression increases resistance to infection by Serratia marcescens; lys-1(RNAi) animals have normal resistance to S. marcescens, perhaps because of genetic redundancy with the LYS-1 paralogs LYS-2 to -8 and LYS-10; in uninfected animals, LYS-1 is expressed in the intestine and in IL1/IL2 neurons, along with a few unidentified head neurons; in intestinal cells, LYS-1 localizes to apical vesicles; LYS-1 expression is induced by infection by Pseudomonas aeruginosa but not S. marcescens; LYS-1 expression is promoted by DBL-1, TIR-1 and NSY-1, and perhaps also by ELT-2, but not by DAF-16; LYS-1 and its paralogs are more similar to lysozymes from the amoeboid protozoon Entamoeba histolytica than to more familiar ones from vertebrates.
GO Process (3)
GO Function (0)
GO Component (2)

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (4)
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