CELE_Y22F5A.4, Y22F5A.4

lys-1 encodes a putative lysozyme, whose overexpression increases resistance to infection by Serratia marcescens; lys-1(RNAi) animals have normal resistance to S. marcescens, perhaps because of genetic redundancy with the LYS-1 paralogs LYS-2 to -8 and LYS-10; in uninfected animals, LYS-1 is expressed in the intestine and in IL1/IL2 neurons, along with a few unidentified head neurons; in intestinal cells, LYS-1 localizes to apical vesicles; LYS-1 expression is induced by infection by Pseudomonas aeruginosa but not S. marcescens; LYS-1 expression is promoted by DBL-1, TIR-1 and NSY-1, and perhaps also by ELT-2, but not by DAF-16; LYS-1 and its paralogs are more similar to lysozymes from the amoeboid protozoon Entamoeba histolytica than to more familiar ones from vertebrates.

44458

6239