Caenorhabditis elegans
MRE-11
CELE_ZC302.1, ZC302.1
mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei.
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- base-excision repair [IBA]
- double-strand break repair [IBA]
- embryo development ending in birth or egg hatching [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IMP]
- intra-S DNA damage checkpoint [IBA]
- lipid storage [IMP]
- meiotic chromosome segregation [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA]
- nucleotide-excision repair [IBA]
- telomere maintenance [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
44517
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- Interactors 19
- Interactions 26
- Network