Grb10: A new substrate of the insulin-like growth factor I receptor.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Using the yeast two-hybrid system, we have isolated a new substrate of the insulin-like growth factor I receptor (IGF-IR), identified as Grb10, a member of the family of SH2 domain proteins. With the help of several mutants of the IGF-IR, we have mapped the binding site of Grb10 between amino acids 1229 and 1245 of the receptor, a sequence that is dispensable for the mitogenic activity of the IGF-IR. Grb10 coprecipitates with the IGF-IR in cell lysates and is probably involved in the regulation of its activity.
Mesh Terms:
Binding Sites, GRB10 Adaptor Protein, Humans, Precipitin Tests, Protein Binding, Proteins, Receptor, IGF Type 2, src Homology Domains
Cancer Res. Jul. 15, 1996; 56(14);3165-7 [PUBMED:8764099]
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