Grb10: A new substrate of the insulin-like growth factor I receptor.
Using the yeast two-hybrid system, we have isolated a new substrate of the insulin-like growth factor I receptor (IGF-IR), identified as Grb10, a member of the family of SH2 domain proteins. With the help of several mutants of the IGF-IR, we have mapped the binding site of Grb10 between amino ... acids 1229 and 1245 of the receptor, a sequence that is dispensable for the mitogenic activity of the IGF-IR. Grb10 coprecipitates with the IGF-IR in cell lysates and is probably involved in the regulation of its activity.
Mesh Terms:
Binding Sites, GRB10 Adaptor Protein, Humans, Precipitin Tests, Protein Binding, Proteins, Receptor, IGF Type 2, src Homology Domains
Binding Sites, GRB10 Adaptor Protein, Humans, Precipitin Tests, Protein Binding, Proteins, Receptor, IGF Type 2, src Homology Domains
Cancer Res.
Date: Jul. 15, 1996
PubMed ID: 8764099
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