CELE_F55A11.3, hrd-1, F55A11.3

sel-11 encodes an E3 ubiquitin ligase; sel-11 was identified in screens for mutations that suppress the egg-laying defective (Egl) phenotype of a hypomorphic lin-12 allele; sel-11 mutations also suppress the temperature-sensitive, maternal-effect embryonic lethality of a glp-1 partial loss-of-function allele; SEL-11 functions as an ER E3 ubiquitin ligase that plays a role in the unfolded protein response (UPR), as well as growth and development of the intestine and gonad.

44637

6239