Caenorhabditis elegans
SCC-3
CELE_F18E2.3, F18E2.3
scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization.
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cell division [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic nuclear division [IMP]
- meiotic sister chromatid cohesion [IMP]
- mitotic sister chromatid segregation [IMP]
- nematode larval development [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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44769
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- Interactors 13
- Interactions 15
- Network