CELE_F57B1.2, mtf-1, F57B1.2

sun-1 encodes a protein member of the SUN-domain family, also called Matefin and is paralogous to UNC-84, whose general domain organization (one or more central transmembrane and coiled-coil domains, followed by a C-terminal SUN domain) is shared by Sad1p from Schizosaccharomyces pombe and UNC-84 from C. elegans; SUN-domain proteins bind lamins and the KASH domain proteins of the outer nuclear membrane; SUN-1 along with the KASH-domain protein ZYG-12, is required for movement, homologous pairing and interhomolog recombination of chromosomes during meiosis; SUN-1 is a nuclear envelope receptor for CED-4 during apoptosis, and is bound by CED-4 in vitro; SUN-1 colocalizes with the nuclear lamin LMN-1 in vivo and binds it in vitro; SUN-1 is required for localization of the hook protein ZYG-12 to the nuclear envelope, and thus for the attachment of centrosomes to nuclei; SUN-1 is strongly expressed in the nuclear envelope of all early embryonic cells, the primordial germ cells Z2 and Z3, and the germ cell lineage (but not in sperm).

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