Caenorhabditis elegans

ATX-3

CELE_F28F8.6, tag-70, F28F8.6
atx-3 encodes a deubiquitylating enzyme that is the C. elegans ortholog of human ataxin-3 (ATXN3); atx-3 deletion mutants show no overt phenotype, but loss of atx-3 activity via RNAi has been reported to result in 10-25% embryonic lethality; however, microarray experiments comparing wild-type and atx-3 mutant strains indicate that loss of atx-3 activity results in expression changes in genes involved in the ubiquitin-proteasome pathway, signal transduction, and cell structure and motility; ATX-3 exhibits deubiquitinating (DUB) activity against polyubiquitin chains in vitro; an ATX-3::GFP reporter is expressed throughout the life cycle in a number of different tissues, with adults showing stronger expression than larvae or eggs; ATX-3::GFP localizes to both the nucleus and the cytoplasm, with higher levels found in the cytoplasm.
GO Process (2)
GO Function (2)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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