Caenorhabditis elegans
PPTR-1
CELE_W08G11.4, W08G11.4
pptr-1 encodes a PP2A holoenzyme regulatory subunit, a member of the B56 family of genes homologous to mammalian PPP2R5B (OMIM: 601644); out of the seven PP2A regulatory subunits only pptr-1 regulates dauer formation downstream of daf-2;pptr-1 controls dauer formation specifically through the IIS pathway; pptr-1 regulates multiple phenotypes associated with the IIS pathways like stress resistance and life span; genetically pptr-1 is at the level of or downstream of akt-1 in IIS pathway; PPTR-1/mammalian B56beta regulatory subunit function to modulate AKT-1 phosphorylation in a conserved manner across phylogeny; changes in PPTR-1 levels affect the activity of AKT-1 and as a result, modulate DAF-16 subcellular localization; PPTR-1 positively regulates DAF-16 nuclear localization and thereby its activity on transcriptional targets; PPTR1 expression is predominantly cytosolic and overlaps with AKT-2 in pharynx, head neurons, nerve ring, spermathecae and vulva.
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- dauer larval development [IGI]
- determination of adult lifespan [IGI, IMP]
- embryo development ending in birth or egg hatching [IMP]
- intracellular signal transduction [IDA]
- protein dephosphorylation [IDA]
- regulation of insulin-like growth factor receptor signaling pathway [IGI]
- regulation of lipid storage [IGI]
- response to heat [IGI]
Gene Ontology Molecular Function
Download Curated Data for this Protein
45089
6239
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- Interactors 14
- Interactions 19
- Network