CELE_Y102A5A.1, Y102A5A.1

cand-1 encodes the ortholog of the human and metazoan CAND1 (cullin-associated and neddylation-dissociated) protein which contains multiple HEAT repeats and binds to the cullin-Rbx1 dimeric complex; cand-1 can physically bind all six cullins in C. elegans and negatively regulates the neddylation of CUL-2 and CUL-4, suggesting that CAND-1 promotes cullin stability, however cullin-dependent cellular functions are unaffected in cand-1 mutants; cand-1 is a positive regulator of Cullin-RING ubiquitin ligases, is required for viability and for the proper development of seam cells, vulva and the tail; CAND-1 is expressed in proliferating cells of the embryo and larvae and a sub-set of non-proliferating larval cells, and is mostly absent from adult somatic tissues; CAND-1 localizes predominantly to the nucleus.

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