Caenorhabditis elegans

UNC-51

CELE_Y60A3A.1, frs-2, atg-1, Y60A3A.1
unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
Download 2 Published Interactions For This Protein
45271
6239
  • Stats & Options
Switch View:
  • Interactors (2)
  • Interactions (2)
  • Network