Caenorhabditis elegans
UNC-51
CELE_Y60A3A.1, frs-2, atg-1, Y60A3A.1
unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5.
GO Process (23)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- autophagic vacuole assembly [IBA]
- autophagy [IGI, IMP]
- axon extension [IMP]
- axon guidance [IMP]
- axonogenesis [IMP]
- cell migration [IMP]
- dauer larval development [IGI]
- determination of adult lifespan [IGI, IMP]
- embryo development ending in birth or egg hatching [IGI]
- growth [IMP]
- locomotion [IMP]
- necrotic cell death [IMP]
- nematode male tail tip morphogenesis [IMP]
- programmed cell death [IGI]
- protein autophosphorylation [IDA]
- protein catabolic process [IMP]
- protein phosphorylation [IDA]
- regulation of autophagy [IBA]
- regulation of axon extension [IMP]
- regulation of cell size [IMP]
- regulation of multicellular organism growth [IGI]
- regulation of protein localization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 11
- Interactions 20
- Network