Caenorhabditis elegans

PRMT-1

CELE_Y113G7B.17, epg-11, Y113G7B.17

prmt-1 encodes a type I protein arginine methyltransferase; in C. elegans, PRMT-1 positively regulates adult lifespan and is required for stress response and fat storage in the absence of DAF-2-mediated signaling; PRMT-1 is also required for proper development of myofilament structure; PRMT-1 physically interacts with, and methylates, DAF-16 thereby preventing its phosphorylation and cytoplasmic retention; in body wall muscle cells, PRMT-1 has been localized to the endoplasmic reticulum.

GO Process (7)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

histone H4-R3 methylation [IBA]

histone arginine methylation [IBA]

locomotion [IMP]

peptidyl-arginine N-methylation [IDA]

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA, IDA]

regulation of transcription, DNA-templated [IBA]

striated muscle myosin thick filament assembly [IMP]

Gene Ontology Molecular Function

histone methyltransferase activity (H4-R3 specific) [IBA]
protein-arginine N-methyltransferase activity [IDA]
protein-arginine omega-N asymmetric methyltransferase activity [IBA, IDA]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

45286

6239

Interactors 39
Interactions 42
Network