CELE_B0250.2, B0250.2

calf-1 encodes a novel Type I transmembrane protein conserved amongst nematodes; CALF-1 is required, along with UNC-36, for proper intracellular trafficking, presynaptic localization, and functional maturation of UNC-2, an alpha 1 subunit of the C. elegans neuronal CaV2 voltage-gated calcium channel, in sensory and motor neurons throughout development; calf-1 also functions in a calcium-dependent pathway that generates left-right asymmetry in the AWC neurons during development; a calf-1::gfp promoter fusion is expressed in many or all neurons, and a CALF-1::GFP reporter fusion localizes to the endoplasmic reticulum.

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