CELE_T03D8.3, T03D8.3

sbt-1 encodes the C. elegans ortholog of the neuroendocrine chaperone 7B2; by homology, SBT-1 is predicted to function in the maturation/activation of the EGL-3/PC2 proprotein convertase; accordingly, mass spectrometry analysis indicates that sbt-1 activity is required for production of some neuropeptides; sbt-1 mutant animals are also aldicarb resistant, suggesting that SBT-1 is required for normal cholinergic signaling; in both in vitro and in vivo assays, SBT-1 facilitates maturation of vertebrate proPC2; sbt-1 promoter fusions are expressed in most neurons and in the pharynx; when expressed in DA cholinergic neurons under the control of the unc-129 promoter, SBT-1::YFP localizes to puncta adjacent to the synaptic vesicle reporter SNB-1::RFP.

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