CELE_C02H7.1, C02H7.1

dyf-11 encodes a conserved protein that is orthologous to mammalian IFT54 (MIP-T3, Traf3ip1) and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport complex B (IFT-B) proteins; DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis; DYF-11 physically interacts with DYF-19, the C. elegans FBF1 (Fas (TNFRSF6)-binding factor 1) ortholog that localizes to ciliary transition fibers; a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons; a DYF-11::GFP protein fusion is detected throughout the cilium and localizes to IFT-B subcomplexes in a manner consistent with an early role in IFT-B subcomplex assembly; dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor.

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