Caenorhabditis elegans


CELE_F35H12.3, sum-1, F35H12.3
sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.
Download Curated Data for this Protein
Switch View:
  • Interactors 57
  • Interactions 58
  • Network