Caenorhabditis elegans
SEL-12
CELE_F35H12.3, sum-1, F35H12.3
sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.
GO Process (15)
GO Function (2)
GO Component (16)
Gene Ontology Biological Process
- Notch receptor processing [IBA]
- Notch signaling pathway [NAS]
- amyloid precursor protein catabolic process [IBA]
- apical protein localization [IDA]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- cell fate specification [IMP]
- detection of temperature stimulus [IMP]
- membrane protein ectodomain proteolysis [IBA]
- negative regulation of apoptotic process [IBA]
- nervous system development [IMP]
- oviposition [IMP]
- positive regulation of Notch signaling pathway [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- growth cone [IBA]
- integral component of plasma membrane [IBA]
- lysosomal membrane [IBA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nucleus [IBA]
- perinuclear region of cytoplasm [IDA]
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- Interactors 57
- Interactions 58
- Network